Disruption of CTCF at the miR-125b1 locus in gynecological cancers and breast cancer cell lines
نویسندگان
چکیده
Background In cancer cells, transcriptional gene silencing has been associated with genetic and epigenetic defects. The disruption of DNA methylation patterns and covalent histone marks has been associated with cancer development. In non-neoplastic cells the multifunctional CCCTC-binding factor (CTCF) can serve as a barrier against the spread of DNA methylation and histone repressive marks into promoter regions of tumor suppressor genes such as BRCA1, Rb, p16 and p53. The absence of CTCF has been related with its epigenetic gene silencing. Until recently, microRNA (miRNA) gene silencing was not well understood. In particular, miR125b1 has been suggested to be a miRNA with tumor suppressor activity, and it has been shown to be deregulated in various human cancers.
منابع مشابه
Role of CTCF in the regulation of microRNA expression
MicroRNAs (miRNAs) are small non-coding RNAs that regulate expression of various target genes. miRNAs are expressed in a tissue-specific manner and play important roles in cell proliferation, apoptosis, and differentiation. Epigenetic alterations such as DNA methylation and histone modification are essential for chromatin remodeling and regulation of gene expression including miRNAs. The CCCTC-...
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